90plus 纳米粒度仪应用案例-16
90plus纳米粒度仪应用案例
文献名：optimizationofβ-caroteneloadedsolidlipidnanoparticlespreparationusingahighshearhomogenizationtechnique
作者：michael d. triplett ii
摘要：usingstatisticalexperimentaldesignmethodologies,thesolidlipidnanoparticledesignspacewasfoundtobemorerobustthanpreviouslyshowninliterature.formulationandhighshearhomogenizationprocesseffectsonsolidlipidnanoparticlesizedistribution,stability,drugloading,anddrugreleasehavebeeninvestigated.experimentationindicatedstearicacidastheoptimallipid,sodiumtaurocholateastheoptimalcosurfactant,anoptimumlecithintosodiumtaurocholateratioof3:1,andaninverserelationshipbetweenmixingtimeandspeedandnanoparticlesizeandpolydispersity.havingdefinedthebasesolidlipidnanoparticlesystem,β-carotenewasincorporatedintostearicacidnanoparticlestoinvestigatetheeffectsofintroducingadrugintothebasesolidlipidnanoparticlesystem.thepresenceofβ-caroteneproducedasignificanteffectontheoptimalformulationandprocessconditions,butthedesignspacewasfoundtoberobustenoughtoaccommodatethedrug.β-caroteneentrapmentefficiencyaveraged40%.β-carotenewasretainedinthenanoparticlesfor1month.asdemonstratedherein,solidlipidnanoparticletechnologycanbesufficientlyrobustfromadesignstandpointtobecomecommerciallyviable.
关键词：solidlipidnanoparticle,lipophileandpoorly-solubledrugdelivery,highshearhomogenization,b-carotene,lipids,bilesalts,statisticalmethodology
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90plus 纳米粒度仪应用案例-16
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文献名：optimizationofβ-caroteneloadedsolidlipidnanoparticlespreparationusingahighshearhomogenizationtechnique
作者：michael d. triplett ii
摘要：usingstatisticalexperimentaldesignmethodologies,thesolidlipidnanoparticledesignspacewasfoundtobemorerobustthanpreviouslyshowninliterature.formulationandhighshearhomogenizationprocesseffectsonsolidlipidnanoparticlesizedistribution,stability,drugloading,anddrugreleasehavebeeninvestigated.experimentationindicatedstearicacidastheoptimallipid,sodiumtaurocholateastheoptimalcosurfactant,anoptimumlecithintosodiumtaurocholateratioof3:1,andaninverserelationshipbetweenmixingtimeandspeedandnanoparticlesizeandpolydispersity.havingdefinedthebasesolidlipidnanoparticlesystem,β-carotenewasincorporatedintostearicacidnanoparticlestoinvestigatetheeffectsofintroducingadrugintothebasesolidlipidnanoparticlesystem.thepresenceofβ-caroteneproducedasignificanteffectontheoptimalformulationandprocessconditions,butthedesignspacewasfoundtoberobustenoughtoaccommodatethedrug.β-caroteneentrapmentefficiencyaveraged40%.β-carotenewasretainedinthenanoparticlesfor1month.asdemonstratedherein,solidlipidnanoparticletechnologycanbesufficientlyrobustfromadesignstandpointtobecomecommerciallyviable.
关键词：solidlipidnanoparticle,lipophileandpoorly-solubledrugdelivery,highshearhomogenization,b-carotene,lipids,bilesalts,statisticalmethodology
影响气体检测仪读数的因素有哪些？
优质佛山到温哥华物流专线_佛山到温哥华物流公司
P164594发电系统液压油格滤清器
东莞到首尔国际物流_东莞到首尔物流货代
广州白云区到台中物流专线直达_优质广州白云区到台中物流公司
90plus 纳米粒度仪应用案例-16
北京27SiMn无缝管市场弱势不改
萃取振荡器实在是液液萃取分离的“利器”
云浮到釜山空运航空运输_云浮到釜山国际航空货代
操作方便的全自动连续包装机性能特点
对于排屑机保养注意的几个细节
安装烟囱航标灯施工
生产线用滚筒式电子台秤功能
天津到东莞空运物流,天津到东莞空运快递,天津到东莞航空货运快件运输
安沃驰传感器SM6-AL系列的使用范围
龙岩到吉隆坡国际空运货代公司_龙岩到吉隆坡航空托运
深圳到晋州空运加急当日达航空,深圳到晋州空运专线宠物托运
超声波清洗机具体的应用范围
上海奉贤区到酉阳县物流公司货运直达,上海奉贤区到重庆酉阳县物流专线
佛山到石家庄货运专线直达运输_佛山到石家庄物流公司