挥发性有机化合物作为胃肠道疾病和营养状况的生物标记
volatile organic compounds as biomarkers of gastrointestinal diseases and nutritional status
挥发性有机化合物作为胃肠道疾病和营养状况的生物标记
mariangela rondanelli ,1,2 federica perdoni,3 vittoria infantino,4 milena anna faliva,3
gabriella peroni ,3 giancarlo iannello,5 mara nichetti,3 tariq a. alalwan,6 simone perna ,6 and clementina cocuzza 7
1irccs mondino foundation, pavia 27100, italy
2department of public health, experimental and forensic medicine, university of pavia, pavia 27100, italy
3endocrinology and nutrition unit, azienda di servizi alla persona “istituto santa margherita”, university of pavia, pavia 27100, italy
4department of biomedical sciences and human oncology, university of bari aldo moro, bari 70121, italy
5general management, azienda di servizi alla persona “istituto santa margherita”, pavia 27100, italy
6department of biology, college of science, university of bahrain, sakhir campus p.o. box 32038, zallaq, bahrain
7department of medicine and surgery, university of milano-bicocca, milano 20126, italy
abstract
the purpose of this review was to identify the best solution for rapid and noninvasive diagnosis and long-term monitoring of patients affected by inflammatory gastrointestinal diseases, colon and gastric cancer, obesity in correlation to diet, and breast milk to evaluate exposure to vocs in women and infants.
本综述的目的是确定快速无创诊断和长期监测炎症性胃肠疾病、结肠癌和胃癌、与饮食相关的肥胖和母乳患者的解决方案，以评估妇女和婴儿接触挥发性有机化合物的情况。
methods.is review included 20 previously published eligible studies. voc analysis has allowed us to highlight differences in lifestyles, intestinal microbiota, and metabolism. new innovative methods have been described that allow the detection and quantification of a broad spectrum of metabolites present in exhaled breath even at very low levels, some of which have been shown to be indicators of pathological conditions.
审查包括20项先前发表的合格研究。挥发性有机化合物分析使我们能够突出生活方式、肠道微生物群和新陈代谢的差异。已经描述了新的创新方法，允许检测和量化呼气中的广泛代谢物，即使在非常低的水平，其中一些已被证明是病理条件的指标。
results.five studies were analyzed that involved voc analysis in relation to type of diet. all of them showed that the type of diet can have an impact on metabolites excreted and therefore can be a useful tool in the nutritional studies related to metabolism and health and disease status. two studies concerned voc analysis in inflammatory bowel diseases, and the results showed that vocs can distinguish active disease from remission; voc profile is clearly different in patients. in particular, c15h30 1-pentadecene, 3-methyl-1-butanal, octane, acetic acid, alpha-pinene, and m-cymene are elevated in active ulcerative colitis. four studies examined vocs in gastric and colorectal tumors showing a change in metabolic biomarkers of cancer patients compared to the control group. finally, the study of vocs in breast milk has improved the understanding of the potential health risks of exposure of children to chemical pollutants. conclusions. voc analysis allowed to highlight differences in behavior, lifestyle, and metabolism of individuals. analytical methods are continuously developed to allow for better detection and quantification of metabolites, thus enabling the detection of a broader spectrum of pathophysiology and disease biomarkers.
五项研究分析了与饮食类型相关的挥发性有机化合物分析。所有这些结果都表明，饮食类型对代谢产物的排泄有影响，因此可以作为营养研究中与代谢、健康和疾病状况相关的有用工具。两项研究涉及炎症性肠病的voc分析，结果表明vocs可以区分活动性肠病和缓解性肠病；患者的voc谱明显不同。尤其是，在活动性溃疡性结肠炎中，c15h30 1-戊烯、3-甲基-1-丁醛、辛烷、乙酸、α-蒎烯和间-聚伞烯含量升高。四项研究检测了胃和结肠肿瘤中的挥发性有机化合物，显示癌症患者的代谢生物标志物与对照组相比发生了变化。后，对母乳中挥发性有机化合物的研究提高了人们对儿童接触化学污染物的潜在健康风险的认识。结论。voc分析可以突出个体在行为、生活方式和新陈代谢方面的差异。分析方法不断发展，以便更好地检测和量化代谢物，从而能够检测更广泛的病理生理学和疾病生物标志物。
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挥发性有机化合物作为胃肠道疾病和营养状况的生物标记
mariangela rondanelli ,1,2 federica perdoni,3 vittoria infantino,4 milena anna faliva,3
gabriella peroni ,3 giancarlo iannello,5 mara nichetti,3 tariq a. alalwan,6 simone perna ,6 and clementina cocuzza 7
1irccs mondino foundation, pavia 27100, italy
2department of public health, experimental and forensic medicine, university of pavia, pavia 27100, italy
3endocrinology and nutrition unit, azienda di servizi alla persona “istituto santa margherita”, university of pavia, pavia 27100, italy
4department of biomedical sciences and human oncology, university of bari aldo moro, bari 70121, italy
5general management, azienda di servizi alla persona “istituto santa margherita”, pavia 27100, italy
6department of biology, college of science, university of bahrain, sakhir campus p.o. box 32038, zallaq, bahrain
7department of medicine and surgery, university of milano-bicocca, milano 20126, italy
abstract
the purpose of this review was to identify the best solution for rapid and noninvasive diagnosis and long-term monitoring of patients affected by inflammatory gastrointestinal diseases, colon and gastric cancer, obesity in correlation to diet, and breast milk to evaluate exposure to vocs in women and infants.
本综述的目的是确定快速无创诊断和长期监测炎症性胃肠疾病、结肠癌和胃癌、与饮食相关的肥胖和母乳患者的解决方案，以评估妇女和婴儿接触挥发性有机化合物的情况。
methods.is review included 20 previously published eligible studies. voc analysis has allowed us to highlight differences in lifestyles, intestinal microbiota, and metabolism. new innovative methods have been described that allow the detection and quantification of a broad spectrum of metabolites present in exhaled breath even at very low levels, some of which have been shown to be indicators of pathological conditions.
审查包括20项先前发表的合格研究。挥发性有机化合物分析使我们能够突出生活方式、肠道微生物群和新陈代谢的差异。已经描述了新的创新方法，允许检测和量化呼气中的广泛代谢物，即使在非常低的水平，其中一些已被证明是病理条件的指标。
results.five studies were analyzed that involved voc analysis in relation to type of diet. all of them showed that the type of diet can have an impact on metabolites excreted and therefore can be a useful tool in the nutritional studies related to metabolism and health and disease status. two studies concerned voc analysis in inflammatory bowel diseases, and the results showed that vocs can distinguish active disease from remission; voc profile is clearly different in patients. in particular, c15h30 1-pentadecene, 3-methyl-1-butanal, octane, acetic acid, alpha-pinene, and m-cymene are elevated in active ulcerative colitis. four studies examined vocs in gastric and colorectal tumors showing a change in metabolic biomarkers of cancer patients compared to the control group. finally, the study of vocs in breast milk has improved the understanding of the potential health risks of exposure of children to chemical pollutants. conclusions. voc analysis allowed to highlight differences in behavior, lifestyle, and metabolism of individuals. analytical methods are continuously developed to allow for better detection and quantification of metabolites, thus enabling the detection of a broader spectrum of pathophysiology and disease biomarkers.
五项研究分析了与饮食类型相关的挥发性有机化合物分析。所有这些结果都表明，饮食类型对代谢产物的排泄有影响，因此可以作为营养研究中与代谢、健康和疾病状况相关的有用工具。两项研究涉及炎症性肠病的voc分析，结果表明vocs可以区分活动性肠病和缓解性肠病；患者的voc谱明显不同。尤其是，在活动性溃疡性结肠炎中，c15h30 1-戊烯、3-甲基-1-丁醛、辛烷、乙酸、α-蒎烯和间-聚伞烯含量升高。四项研究检测了胃和结肠肿瘤中的挥发性有机化合物，显示癌症患者的代谢生物标志物与对照组相比发生了变化。后，对母乳中挥发性有机化合物的研究提高了人们对儿童接触化学污染物的潜在健康风险的认识。结论。voc分析可以突出个体在行为、生活方式和新陈代谢方面的差异。分析方法不断发展，以便更好地检测和量化代谢物，从而能够检测更广泛的病理生理学和疾病生物标志物。
低温等离子油烟净化器的五大特点
拉曼光谱分析仪厂家
汽车衡的原理和结构！
污水处理厂氨氮超标的原因与处理方法
IPF光电传感器的三大显著特性你都知道吗？
挥发性有机化合物作为胃肠道疾病和营养状况的生物标记
影响中走丝线切割加工工件表面质量的材料因素的控制与改善
EOCR电动机保护器失速与堵转保护功能的使用方法
怎么才能延长实验室冻干机的使用寿命
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养虫管 平底养虫管 养蚊管微小昆虫采集管 型号：HL-CJG
学校启动“陪餐制” 洗碗、消毒设备共同把关餐食安全
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