Broadpharm什么是电离脂质Ionizable Lipids？
what are ionizable lipidsionizable lipids are a class oflipid moleculeswhich remain neutral at physiological ph, but are protonated at low ph, making them positively charged,alc-0315(figure 1) is an example with the amine site that can be protonated at low ph.
figure 1:structure of alc-0315
ionizable lipidsare one key component of ionizable lipid nanoparticles (lnps) which have been widely used for the systemic delivery of rna therapeutics. other lipid molecules in lnps include helper lipid, cholesterol, and peg lipid, etc.
commonly reported ionizable lipid materials were reported for lnp formulations include c12-200, ckk-e12, and dlin-mc3-dma). these lnps showed an efficient gene silencing in the liver at the dosing level of 0.002 mg of sirna/kg.
why use ionizable lipids?the ph-sensitivity of ionizable lipids is beneficial for mrna delivery in vivo, because neutral lipids have less interactions with the anionic membranes of blood cells which improves the biocompatibility of lipid nanoparticles. trapped in endosomes, in which the ph is lower than the ph in the extracellular environment, ionizable lipids are protonated and become positively charged, which may promote membrane destabilization and facilitate endosomal escape of the nanoparticles. ionizable lipids promote endosome escape and reduce toxicity of lipid nanoparticles (lnp).
lipid supplier and customer synthesisas a leading biochemical supplier worldwide, broadpharm offer a wide array of lipid molecules, such asionizable lipids,cationic lipids,helper lipids,peg lipidsto our clients worldwide. broadpharm also provides fast speed custom synthesis of novel lipid molecules to empower your advanced research.
journal reference:1.x. hou, t. zaks, r. langer, y. dong, nature review materials, (2021)
2.y. dong, k. love, j. dorkin, et.al.lipopeptide nanoparticles for potent and selective sirna delivery in rodents and nonhuman primates. proc. natl. acad. sci. u.s.a. 111, 3955-3960 (2014).
美国linemaster 2E-20V2-S脚踏开关应用于什么
奥美斯橡塑保温板厂家专卖店
DEIF隔离器 SIM-Q MKII 技术参数
山东机房橡塑保温施工一米多少钱
玻璃升降反应釜相比传统反应器具有怎样的优势呢？
Broadpharm什么是电离脂质Ionizable Lipids？
实验室废水cod测定仪的常见故障及解决方法
如何安装定硫仪的送样棒
导致高压鼓风机出现故障的因素有几点
蛹虫草速溶粉
污水站除臭设备的创新与实践
辣椒烘干时保护辣椒红素和营养价值的zui适宜的温度
金昌市室外薄型钢结构防火涂料价格/出厂价格
概述阻燃橡塑保温板所具有的几点优势
使用Zeta电位分析仪的流程分为几步
油烟浓度在线监测系统生产厂家
红外辐射测温所依据的客观基础
造模新方向—CRISPR-Cas9基因编辑类器官模型
冷光源6个常见故障及处理方法
热电偶安装用法兰套管规格型号字母含义说明
figure 1:structure of alc-0315
ionizable lipidsare one key component of ionizable lipid nanoparticles (lnps) which have been widely used for the systemic delivery of rna therapeutics. other lipid molecules in lnps include helper lipid, cholesterol, and peg lipid, etc.
commonly reported ionizable lipid materials were reported for lnp formulations include c12-200, ckk-e12, and dlin-mc3-dma). these lnps showed an efficient gene silencing in the liver at the dosing level of 0.002 mg of sirna/kg.
why use ionizable lipids?the ph-sensitivity of ionizable lipids is beneficial for mrna delivery in vivo, because neutral lipids have less interactions with the anionic membranes of blood cells which improves the biocompatibility of lipid nanoparticles. trapped in endosomes, in which the ph is lower than the ph in the extracellular environment, ionizable lipids are protonated and become positively charged, which may promote membrane destabilization and facilitate endosomal escape of the nanoparticles. ionizable lipids promote endosome escape and reduce toxicity of lipid nanoparticles (lnp).
lipid supplier and customer synthesisas a leading biochemical supplier worldwide, broadpharm offer a wide array of lipid molecules, such asionizable lipids,cationic lipids,helper lipids,peg lipidsto our clients worldwide. broadpharm also provides fast speed custom synthesis of novel lipid molecules to empower your advanced research.
journal reference:1.x. hou, t. zaks, r. langer, y. dong, nature review materials, (2021)
2.y. dong, k. love, j. dorkin, et.al.lipopeptide nanoparticles for potent and selective sirna delivery in rodents and nonhuman primates. proc. natl. acad. sci. u.s.a. 111, 3955-3960 (2014).
美国linemaster 2E-20V2-S脚踏开关应用于什么
奥美斯橡塑保温板厂家专卖店
DEIF隔离器 SIM-Q MKII 技术参数
山东机房橡塑保温施工一米多少钱
玻璃升降反应釜相比传统反应器具有怎样的优势呢？
Broadpharm什么是电离脂质Ionizable Lipids？
实验室废水cod测定仪的常见故障及解决方法
如何安装定硫仪的送样棒
导致高压鼓风机出现故障的因素有几点
蛹虫草速溶粉
污水站除臭设备的创新与实践
辣椒烘干时保护辣椒红素和营养价值的zui适宜的温度
金昌市室外薄型钢结构防火涂料价格/出厂价格
概述阻燃橡塑保温板所具有的几点优势
使用Zeta电位分析仪的流程分为几步
油烟浓度在线监测系统生产厂家
红外辐射测温所依据的客观基础
造模新方向—CRISPR-Cas9基因编辑类器官模型
冷光源6个常见故障及处理方法
热电偶安装用法兰套管规格型号字母含义说明